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Also, monitor for symptoms of gastrointestinal GI perforation e. Coadministration may decrease plasma concentrations of erlotinib. The pooled incidence of GI perforation clinical trials of erlotinib ranged from 0.

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Drugs known to induce CYP3A4 may lead to decreased esomeprazole plasma concentrations. The manufacturer of esomeprazole recommends avoidance with strong inducers because decreased exposure of esomeprazole can occur.

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Major Monitor for clinical efficacy of etoposide if used concomitantly with dexamethasone. Coadministration of etoposide with a strong CYP3A4 inducer phenytoin resulted in increased etoposide clearance and reduced efficacy, as did coadministration with a weak inducer of CYP3A4 and P-glycoprotein P-gp valproic prix Discount Ondansetron.

Major Dexamethasone can induce the activity of CYP3A4 and increase the metabolism of etravirine; decreased antiviral efficacy may be seen. While concomitant administration has not been evaluated, a potentially significant interaction may occur. Use these drugs concomitantly with caution, or consider alternative corticosteroids, particularly for long-term use.

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FDA-approved labeling for extended-release ER guanfacine recommends that, if these agents are taken together, doubling the recommended dose of guanfacine should be considered; if dexamethasone is added in a patient already receiving guanfacine, this escalation should occur over 1 to 2 weeks. If dexamethasone is discontinued, decrease the guanfacine ER dosage back to the recommended dose over 1 to 2 weeks. Specific recommendations for immediate-release IR guanfacine are not available.

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Concurrent use may result in significant decreases in the plasma concentrations of isavuconazole, leading to a reduction of antifungal efficacy and the potential for treatment failure. Moderate A dose adjustment of dexamethasone may be necessary when administered concurrently with rifamycins, due to the potential for decreased exposure of dexamethasone. Moderate The risk of cardiac toxicity with isoproterenol in asthma patients appears to be increased with the coadministration of corticosteroids.

Intravenous infusions of isoproterenol in refractory asthmatic children at rates of 0. Minor Both isotretinoin and corticosteroids can cause osteoporosis during chronic use. Patients receiving systemic corticosteroids should receive isotretinoin therapy with caution. Moderate Monitor for corticosteroid-related adverse effects and altered response to itraconazole if coadminsitration is necessary, Prix Discount Ondansetron.

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Caution should be utilized when CYP3A4 inducers are coadministered with ixabepilone, and alternative therapies with low enzyme induction potential should be considered. Moderate Coadministration may result in increased exposure to dexamethasone and increased corticosteroid-related adverse effects. In addition, ketoconazole alone can inhibit adrenal corticosteroid synthesis and may cause adrenal insufficiency during corticosteroid withdrawal. Major Avoid coadministration of lapatinib with dexamethasone due to decreased plasma prixes Discount Ondansetron of lapatinib.

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Monitor for changes in clinical response to both lorlatinib and dexamethasone; consider increasing the dose of dexamethasone if clinically appropriate.

Depending upon the relative importance of each drug, discontinue lorlatinib or dexamethasone for persistent Grade 2 or higher hepatotoxicity. The effect of the concomitant use of moderate CYP3A inducers on lorlatinib pharmacokinetics or the risk of hepatotoxicity with the concomitant use of moderate CYP3A inducers is unknown. Drugs that induce CYP3A4 may enhance the metabolism of dexamethasone, requiring a dose increase.

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Monitor the patient for decreased corticosteroid efficacy or increased or prolonged therapeutic effects and adverse events. Additionally, ivacaftor exposure could theoretically be further decreased when given with another CYP3A inducer; however, ivacaftor; lumacaftor dosage adjustments are not recommended with concomitant use of a moderate CYP3A inducer such as dexamethasone.

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